Allopregnanolone: From molecular pathophysiology to therapeutics. A historical perspective
Allopregnanolone is synthesized in the central nervous system either de novo from cholesterol or from steroid Vitamins hormone precursors like progesterone and pregnenolone.Over the past 30 years, direct and rapid, non-genomic actions of allopregnanolone and its derivatives via GABAA receptors have been demonstrated.Changes in brain levels of allop